Fig. 2.
Three states of VSD2. View of VSD2 in the membrane plane from the center of the channel looking outward that illustrates the rotation and twisting of VSD2 helices S7, S8, S9, and S10. Connections to the pore domains are omitted for clarity. S10 is highlighted in each state with a different color than the other helices. Gating charges R1–R3 (R537, R540, and R543) and CT residue Y475 are shown. (Left) Resting-state AtTPC1WT (red, PDB ID code 5DQQ), (Center) AtTPC1DDE state 1 (blue), and (Right) AtTPC1DDE state 2 (pink).