Fig. 1.

MM network and graph. (A) Enzyme $E$ catalyzes formation of product $P$ from substrate $S$ through the intermediate enzyme–substrate complex $ES$, with the indicated rate constants for mass-action kinetics. (B) Corresponding linear framework graph. The vertices are the fast components in the timescale separation, $E$ and $ES$, with the slow component, $S$, appearing in the edge label. The colors refer to Fig. 2.