Table 1:

Baseline characteristics of five patients with classic congenital adrenal hyperplasia on long-term continuous subcutaneous hydrocortisone infusion therapy

Pt	Age/ Sex	Phenotype	Glucocorticoid Dose as hydrocortisone a equivalent (mg/day)	BMI (kg/m2)	Insulin Resistance b	Fatty Liver c	Low BMD d	GI Intolerance to GC	TART /PCOS e	Adrenal mass/ hypertrophy	Hirsutism i
1	25/M	SW	40	34.8	+	+	−	+	+	+ f	NA
2	38/F	SW	50	39.8	+	+	−	−	+	+ f, g	+
3	32/F	SW	32.5	54.1	+	+	+	+	+	−	+
4	25/F	SV	25	40.3	+	−	+	+	+	−	+
5	41/M	SW	25	27.7	−	−	+	−	+	+ f	NA

Abbreviations: Pt, patient; BMI, body mass index; BMD, bone mineral density; GI, gastrointestinal; GC, glucocorticoid; TART, testicular adrenal rest tissue; PCOS, polycystic ovary syndrome; M, Male; F, Female; SV, simple virilizing; SW, salt-wasting; +, present; −, not present; NA, not applicable.

^aGlucocorticoid equivalent dose (mg/day): hydrocortisone X 1, prednisone and prednisolone X 5, and dexamethasone X 80 (2)

^bHOMA-IR > 2.6

^cAST/ALT <1 or steatosis by ultrasound

^dDEXA T-score <−1

^e12 or more follicles 2–9 mm in diameter and/or an increased ovarian volume > 10 mL by ultrasound (9)

^fBilateral adrenal hyperplasia

^gAdrenal adenoma

ⁱHirsutism was defined as a Ferriman-Gallwey total score ≥ 8 (8)