Figure 1.

Finding each FAZ metric using our custom MATLAB script. All four metrics are found with a single segmentation shown in teal. Area is defined as the area within the FAZ segmentation boundary. Acircularity compares the perimeter of the FAZ segmentation to the perimeter of a perfect circle with the same area. For axis ratio and the MHAA, we use the ellipse (defined by regionprops) with the same normalized second central moments as the FAZ masked region. Axis ratio is ratio of the major to the minor axis of this ellipse (longest to shortest axis ratio), while the MHAA is the angle at which the major axis of the ellipse occurs relative to the horizontal axis.