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. 2018 Oct 1;15(10):e1002666. doi: 10.1371/journal.pmed.1002666

Table 3. Five-year relative survival ratios (RSRs) and 5-year excess hazard ratios (EHRs) in relation to high-risk human papillomavirus (hrHPV) status in the 2 main histological types of invasive cervical cancer.

Histological type and hrHPV status Cases (n = 2,635) Deaths (n = 1,021) 5-year RSR (95% CI) 5-year EHR (95% CI)
Crude Adjusted*
SCC, hrHPV− 374 190 0.59 (0.53–0.64) Ref Ref
SCC, hrHPV+ 1,735 665 0.73 (0.70–0.75) 0.56 (0.46–0.68) 0.68 (0.56–0.82)
AC, hrHPV− 116 81 0.45 (0.35–0.55) 1.48 (1.09–2.01) 1.44 (1.07–1.97)
AC, hrHPV+ 410 85 0.87 (0.83–0.90) 0.23 (0.17–0.33) 0.61 (0.43–0.87)

Adenosquamous cell carcinoma (n = 119) and other rare carcinomas (n = 91) are not included in this analysis.

*EHRs were adjusted for age at cancer diagnosis as a spline term with 5 degrees of freedom, time since cancer diagnosis in 1-year bands, International Federation of Gynecology and Obstetrics (FIGO) stage, and education.

AC, adenocarcinoma; SCC, squamous cell carcinoma.