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. 2018 Oct 1;13(10):e0204967. doi: 10.1371/journal.pone.0204967

Fig 3. Paneth cell-depletion induced changes in the microbiome are not dependent on dithizone.

Fig 3

Normal cecal microbiomes were compared between P14 non-treated wild type C57Bl6 mice and PC-DTR mice (on C57Bl6 background). (A) PC-DTR mice had no significant differences in taxa compared to wild type mice of the same age n = 6 for each treatment. (B) Paneth cell depletion using DTX induces significant changes in the microbiota composition by 24 hours in Deferribacteres (7% in Sham vs 28% in DTX treated, p = 0.0004) and in Proteobacteria (46% in Sham vs 27% in DTX treated, p = 0.001), but these significant changes disappear and shift back towards normal floral composition after 72 hours.