Table 4.

Hydrogel-based delivery systems, including cell lines/animal models used for cervical cancer therapy.

S. No.	Drug/therapy/functional group	Type/Composition of gel	Cell lines /animal models/neoplasm	References
1.	Paclitaxel	Poly-N-isopropylacrylamide, tert-butyl 2-acrylamidoethyl carbamate and N-hydroxyethyl acrylamide	MCF7, T47D, and HeLa cells	[115]
2.	Doxorubicin	Fe3O4 magnetic nanoparticle-incorporated poly-(N-isopropylacrylamide)-chitosan-based nanohydrogels	HeLa cells	[116]
3.	Photothermal therapy	Hydrogel system containing polyacrylamide-based nanoparticles	HeLa cells	[117]
4.	Doxorubicin	Cryogel formulations based on chitosan-gelatin, chitosan-agarose and chitosan-agarose gelatin	HeLa cells	[118]
5.	Arginine-glycine-aspartic acid-serine	Magnetic iron oxide nanoparticles coated with polyethylene glycol hydrogel	HeLa cells	[119]
6.	5-fluorouracil	Pluronic F127 together with alternative mucoadhesive polymers, e.g. hyaluronic acid, Carbopol 934, and hydroxypropyl methylcellulose	HeLa cells	[120]
7.	Paclitaxel	Temperature-sensitive poly(organophosphazene)–PTX conjugate	HeLa cells and nude mice	[121]
8.	Doxorubicin, cyclophosphamide and cisplatin	Chitosan hydrogel	Mice containing TC-1 cervical cells	[122]
9.	5-aminolevulinic acid (5-ALA) ester hexylamionolevulinate	Poloxamer 407	Cervical intraepithelial neoplasia	[123,124]