Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Dev Dyn. 2018 Jan 5;247(4):571–580. doi: 10.1002/dvdy.24609

Figure 1. Slit2 and netrin1: Different mechanisms to regulate local translation?

Figure 1

A) A model for indirect regulation of local translation by the axon guidance cue Slit2. Slit2 causes the miRNA miR-182 to release cofilin1 mRNA, potentiating cofilin1 local translation and resulting in growth cone collapse. B) A model for direct regulation of local translation by netrin1-Dcc signaling. Dcc interacts with translational machinery through the conserved P1 motif indicated. Interaction between netrin1 and Dcc induces the release of monosomes from Dcc, allowing them to form polysomes and translate mRNAs locally. Netrin1 mediates the asymmetric translation of beta-actin, resulting in attractive turning. The induction of beta-actin translation by netrin could be due to the direct release of translational machinery from Dcc, or through an alternative mechanism via cytoplasmic proteins that link netrin signaling with translational machinery.