Table 1. The targets and mechanisms for cue-dependent local translation.

Sema3, Slit2, and netrin1 all induce local translation of specific mRNAs. Thus far, two mechanisms have begun to be elucidated: Slit2 indirectly induces local translation of cofilin1 by antagonizing miR-182, and netrin1 causes Dcc to directly release translation machinery, allowing local translation to occur.

Ligand	Receptor	Translation target	Mechanism
Sema3A	Nrp1	Rhoa, nfpc	?
Slit2	Robo2/3	cofilin1	Indirect- Slit2 signaling antagonizes the microRNA miR-124, resulting in the release of cofilin1 mRNA
netrin1	Dcc?	Beta-actin, Dscam, Sensorin	?
netrin1	Dcc	?	Direct-interaction between Dcc and translational machinery