Table 3.
Correlations Among Paracrine Factors, Proliferation, and Angiogenesis
| Liver Tumor, Combined | HBL | HCC | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ki67+ RDs (%) | Ki67+ Area in ITA (%) | No. of CD34+ Vessels in PTA | CD34+ Area in PTA (%) | No. of CD34+ Vessels in ITA | CD34+ Area in ITA (%) | Ki67+ RDs (%) | Ki67+ Area in ITA (%) | No. of CD34+ Vessels in PTA | CD34+ Area in PTA (%) | No. of CD34+ Vessels in ITA | CD34+ Area in ITA (%) | Ki67+ RDs (%) | Ki67+ Area in ITA (%) | No. of CD34+ Vessels in PTA | CD34+ Area in PTA (%) | No. of CD34+ Vessels in ITA | CD34+ Area in ITA (%) | ||
| EpCAM+ area in NTA (%) |
0.0919*
0.6353† |
0.0525 0.7830 |
–0.2260 0.2207 |
0.1136 0.5358 |
0.0934 0.6113 |
0.0285 0.8768 |
0.1823 0.4839 |
0.1558 0.5371 |
–0.1312 0.5813 |
0.0974 0.6828 |
0.1869 0.4301 |
–0.1295 0.5865 |
–0.0066 0.9838 |
–0.1292 0.6890 |
–0.4240 0.1695 |
0.1588 0.6220 |
–0.1039 0.7480 |
0.3563 0.2556 |
|
| No. of peritumoral RDs (per mm2) |
–0.1308 0.4989 |
0.4671 0.0093 |
0.2595 0.1515 |
0.1298 0.4788 |
0.1088 0.5532 |
0.1837 0.3143 |
0.0168 0.9490 |
0.5046 0.0327 |
0.1305 0.5834 |
0.3091 0.1848 |
0.1951 0.4097 |
0.1548 0.5148 |
–0.3400 0.2888 |
0.2269 0.4782 |
0.5430 0.0681 |
–0.4907 0.1053 |
–0.3183 0.3134 |
0.0600 0.8531 |
|
| VEGF+ RDs (%) |
–0.0707 0.7154 |
0.3262 0.0785 |
–0.2933 0.1033 |
–0.0789 0.6677 |
–0.1266 0.4901 |
–0.0340 0.8533 |
0.2292 0.3763 |
0.3447 0.1613 |
–0.4058 0.0758 |
0.0014 0.9953 |
–0.1651 0.4866 |
–0.0765 0.7487 |
–0.2958 0.3506 |
0.1153 0.7213 |
0.2085 0.5156 |
–0.2987 0.3456 |
–0.4139 0.1810 |
0.1128 0.7270 |
|
| VEGFD+ RDs (%) |
–0.2257 0.2391 |
0.1430 0.4509 |
0.0996 0.5876 |
–0.1576 0.3890 |
–0.1403 0.4437 |
–0.0207 0.9103 |
–0.3154 0.2175 |
–0.1543 0.5409 |
–0.0331 0.8898 |
–0.1680 0.4789 |
–0.2953 0.2062 |
–0.2084 0.3779 |
–0.1243 0.7002 |
0.2696 0.3967 |
0.2131 0.5060 |
–0.1930 0.5485 |
–0.0330 0.9190 |
0.0818 0.8004 |
|
| ANGPT1+ RDs (%) |
0.4567 0.0128 |
0.0227 0.9051 |
–0.1900 0.2975 |
–0.3562 0.0454 |
–0.2657 0.1417 |
–0.4556 0.0088 |
0.5851 0.0136 |
0.0508 0.8414 |
–0.2918 0.2119 |
–0.5219 0.0183 |
–0.2747 0.2412 |
–0.6356 0.0026 |
0.2672 0.4012 |
0.4949 0.1018 |
0.1247 0.6995 |
–0.0905 0.7797 |
–0.1978 0.5378 |
–0.0174 0.9573 |
|
| PDGFC+ RDs (%) |
0.1363 0.4809 |
0.4712 0.0099 |
–0.1271 0.4957 |
–0.1508 0.4180 |
0.0362 0.8469 |
0.1964 0.2896 |
0.3710 0.1427 |
0.3426 0.1782 |
–0.4522 0.0519 |
–0.2866 0.2341 |
–0.1046 0.6700 |
–0.1512 0.5366 |
0.0448 0.8900 |
0.4907 0.1052 |
0.0867 0.7887 |
–0.0073 0.9821 |
0.1310 0.6849 |
0.5070 0.0918 |
|
*Pearson correlation coefficient (r).
† P value.
Abbreviations: ITA, intratumoral area; NTA, nontumoral area; PTA, peritumoral area.