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. 2018 Sep 27;2(10):1213–1226. doi: 10.1002/hep4.1232

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© 2018 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Theoretical model of NR functions in the development of NASH. NR functions (in the presence of their respective ligands) are potentially protective against the development of NASH. Drugs targeting the pictured PPARδ, PPARγ, and FXRα receptors are in trials for the treatment of NASH and the metabolic syndrome. NR–NR heterodimers and interactions are not pictured. (Figure 3 was created by Dr. Nikita Consul, Columbia University College of Physicians and Surgeons, 2017). Abbreviations: ER, endoplasmic reticulum; ROS, reactive oxygen species.