Fig. 2.
BMP7 mRNA levels are decreased in the brains of BMP7 heterozygous mice. Brain mRNA levels for BMP7, PGK1 and HPRT1 were measured in adult BMP7 +/+ (n=5) and +/− mice (n=5) by qRT-PCR. For each sample, mRNA levels for genes of interest were normalized to the housekeeping gene HPRT1 mRNA level. Another housekeeping gene PGK1 mRNA level did not differ between +/+ and +/− mice. BMP7 mRNA level is significantly decreased (50%) in +/− mice compared with the level in +/+ mice (* P<0.005, Student’s t-test).