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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Neuroscience. 2007 Nov 13;151(1):92–103. doi: 10.1016/j.neuroscience.2007.10.044

Fig. 4.

Fig. 4.

Behavioral interactions of BMP7 and MA in CD1 and BMP7 transgenic mice. Daily locomotor activity after MA injection was normalized by comparison to the average activity on day 1 from the control mice. (A) In CD1 mice, MA alone (—■—) reduced locomotor activity. Administration of BMP7 (—∇—) significantly antagonized the MA-mediated decrease in (A1) total distance traveled, (A2) movement time, and (A3) horizontal activity (P<0.05). (B) MA also suppressed the locomotor activity in BMP7 +/− (—▲—) and +/+ (—●—) mice. There is a significant difference (P<0.05) in total distance traveled and movement time and marginal difference (P=0.087) in horizontal activity between BMP7 +/− and BMP7 +/+ mice, with the +/− mice showing a greater MA effect.