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. 2018 Sep 12;9(4):341–345. doi: 10.1007/s12687-018-0382-4

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — The main groups of congenital disorders. The image is notional: there is no relation between frequency and the size of the circles, or actual extent of overlap between categories. MGDb currently includes only the groups whose birth prevalence is relatively constant or can be calculated, namely chromosomal disorders, early-onset congenital malformations, single-gene disorders and two examples of common early-onset disorders due to genetic risk factors—rhesus haemolytic disease and neonatal jaundice due to glucose-6-phosphate dehydrogenase deficiency.