Table 6.
Estimated mean life expectancy with congenital disorders 2010–2014
| Major category | Diagnostic group | Mean life expectancy, years | Years gained per affected person | |
|---|---|---|---|---|
| No care | Optimal care | |||
| Congenital malformations | Anencephaly | 0 | 0 | 0 |
| Spina bifida and encephalocele | 0.5 | 41.2 | 40.7 | |
| Cleft palate Cleft lip +/− cleft palate |
4.4 | 73 | 68.6 | |
| Very severe CHD | ||||
| Severe CHD | 2 | 6.6 | 4.6 | |
| CNS not neural tube defect | 15.8 | 63.6 | 47.8 | |
| Eye | 0.5 | 42.5 | 42 | |
| Ear, face, neck | 39.6 | 74.7 | 35.1 | |
| Respiratory system | 72.2 | 72.2 | 0 | |
| Digestive system | 15.6 | 51 | 35.4 | |
| Abdominal wall defects | 3.8 | 63.3 | 59.5 | |
| Urinary system | 0.5 | 65.1 | 64.6 | |
| Multiple malformations | 10.6 | 69.3 | 58.7 | |
| Genital system | 0.5 | 37.5 | 37 | |
| Limb | 76.7 | 76.7 | 0 | |
| Congenital hypothyroidism | 69.8 | 74.2 | 4.4 | |
| Pyloric stenosis | 11.5 | 80 | 68.5 | |
| Chromosomal disorders | Down syndrome | 0.5 | 80 | 79.5 |
| Other trisomies (+13, +18) | 7.7 | 50.6 | 42.9 | |
| Other autosomal | 0.1 | 0.1 | 0 | |
| Turner syndrome (XO) | 6.9 | 45.6 | 38.7 | |
| Klinefelter syndrome (XXY) | 56.8 | 67.8 | 11 | |
| Inherited disorders | Dominant | 66.4 | 66.4 | 0 |
| X-linked | 1.3 | 17.6 | 16.3 | |
| Recessive disorders | 12.1 | 39.4 | 27.3 | |
| Consanguinity-associated recessive disorders | 6.7 | 28.1 | 21.4 | |
| Sickle cell disorders | 6.7 | 28.1 | 21.4 | |
| Thalassaemia | 3 | 41.5 | 38.5 | |
| Oculocutaneous albinism | 2.4 | 65.1 | 62.7 | |
| Rhesus haemolytic disease | 30 | 70 | 40 | |
| G6PDd kernicterus | 1.9 | 80 | 78.1 | |