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Required information size to demonstrate or reject 15% relative risk reduction of the effect of a strict blood pressure target on the incidence of PDR or macular edema (with a control group proportion of 13.1%, alpha of 5%, and beta of 20%) is 11,572 patients (vertical red dashed line). The red dashed lines represent the trial sequential monitoring boundaries and the futility boundaries. The solid blue line is the cumulative Z curve
