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. 2018 Oct 1;8:14566. doi: 10.1038/s41598-018-32536-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alignment of MscL sequences. Full-length sequences of Mycobacterium tuberculosis MscL, Staphylococcus aureus MscL, Escherichia coli MscL and Methanosarcina acetivorans MscL were aligned using Clustal Omega. The sequence identities between pairs of sequences are MtMscL to SaMscL 40.5%, MtMscL to EcMscL 35.2%, and MtMscL to MaMscL 29.2%. The red triangle over the sequence alignment depicts the location of the (C) terminal truncation after residue 101 of MtMscLΔC. The blue shadings represent sequence identity gradients. The locations of the secondary structure regions are labeled based on the structure for MtMscL, PDBID 2OAR. The residue number legend in green along the top of the alignment corresponds to MtMscL, while the residue numbers on either side of the sequences correspond to that particular homolog. High variability is evident in the periplasmic loop among the homologs.