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. 2018 Oct 1;9:4011. doi: 10.1038/s41467-018-06224-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Gene expression pattern of Tgfbr2-deficient microglia indicates microglia activation and increased immune responses. a A timeline depicting TAM-treatment and microglia isolation/sorting for RNA isolation. b Heatmap analysis of RNAseq expression data of microglia isolated after TAM-induced recombination of Cx3cr1^CreERT2:R26-yfp,Tgfbr2^fl/fl mice (n = 6). TAM-induced Cx3cr1^+/+:R26-yfp,Tgfbr2^fl/fl mice (n = 6) were used as controls displaying no significant changes in expression of microglia-specific genes in Tgfbr2-deficient microglia. c Heatmap analysis of RNAseq expression data showing differentially expressed genes in Tgfbr2-deficient microglia. d GO term enrichment analysis of biological process (GOTERM_BP), e molecular function (GOTERM_MF) and f KEGG pathway enrichment analysis was performed using DAVID Bioinformatics Resources 6.8. g Scheme for microglia cellular compartment enrichment analysis is depicted with individually regulated compartment-associated genes