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. 2018 Oct 1;8:14568. doi: 10.1038/s41598-018-32647-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Amino acid variability by cycle phase. Mean log intensity is depicted along with individual variability for threonine, ornithine, arginine, alanine, glycine, serine, methionine, asparagine, proline, glutamine, tyrosine, gamma-glutamyl-alanine, citrulline, o-acetyl-serine, alpha-aminobutyric acid, and gamma-glutamylglutamine at one time point for each of the 5 menstrual phases (M = menstrual, F = follicular, O = periovular, L = luteal, p = premenstrual). Each colored line represents an individual. Amino acids are depicted which have 2 or more contrast comparisons meeting the multiple testing threshold of q < 0.20. Statistically significant luteal phase reductions can be observed.