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. 2018 Sep 25;9:1018. doi: 10.3389/fphar.2018.01018

FIGURE 1.

FIGURE 1

MgIG reduced expression of fibrotic markers in TGF-β-activated hepatic stellate cells LX2. (A) 1 mg/ml MgIG inhibited TGF-β-induced mRNA expression of both αSMA and collagen-1 at 24 h treatment (T+M), although the decrease in αSMA expression was not statistically significant. The increase in collagen-1 mRNA expression at 48 h treatment was also found to be significantly inhibited by MgIG. Data represents means ± SE of three biological replicates, one-way ANOVA with Tukey HSD test, p-value < 0.05, ∗significance against non-treated control (NegCtrl), #significance against TGF-β treatment. (B) Western blot analyses detected a reduction in protein levels of both αSMA and collagen-1 after treatment with 1 mg/ml MgIG up to 72 h.