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. 2018 Sep 25;9:398. doi: 10.3389/fgene.2018.00398

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Copyright © 2018 Klages-Mundt, Kumar, Zhang, Kapoor and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Incorporation of actin and Arps in chromatin-modifying complexes. The chromatin remodeling complexes INO80, SWR1, SWI/SNF, and RSC, as well as the histone acetyltransferase NuA4, each contain a combination of actin and/or actin-related proteins (Arps) as important stoichiometric subunits. The respective human orthologs of SWI/SNF and RSC – BAF and PBAF – exhibit evolutionary divergence from their counterparts in yeast. Structural and functional differences in these human complexes compared to SWI/SNF and RSC are denoted in green.