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. 2018 Sep 25;9:418. doi: 10.3389/fgene.2018.00418

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Copyright © 2018 Yuan, Volckaert, Chanda, Thannickal and De Langhe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fgf10-expressing lipofibroblasts are a source of activated myofibroblasts, which re-acquire lipogenic fate during fibrosis resolution. During homeostasis, lipofibroblasts (LIFs) express Fgf10 and are near alveolar type II (AT2) cells. In response to bleomycin-mediated alveolar epithelial injury, LIFs undergo a lipogenic to myogenic switch in fibroblastic phenotype and upregulate Fgf10 expression. Vice versa, during fibrosis resolution, myofibroblasts re-acquire lipofibroblast fate yet retain high Fgf10 expression. Solid cell borders represent lineage labels to follow the fate of (lipo)fibroblasts.