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. 2018 Sep 25;9:2173. doi: 10.3389/fimmu.2018.02173

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Copyright © 2018 Marschner, Mulay, Steiger, Anguiano, Zhao, Boor, Rahimi, Inforzato, Garlanda, Mantovani and Anders.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lack of PTX3 induces hyperoxaluria-induced nephrocalcinosis in non-susceptible B6;129SV mice. Female PTX3-competent (Ptx3^+/+) and -deficient (Ptx3^−/−) animals with 10–12 weeks of age received oxalate chow for 3 weeks (n = 9). (A) Oxalic acid levels in urine at baseline and after 3 weeks of oxalate chow. (B) Quantification of calcium oxalate crystal deposition was conducted using Pizzolato's method on formalin fixed kidney sections as shown in (C). (D) Analysis of PTX3^−/− kidneys by X-ray diffraction consistent with calcium-oxalate monohydrate crystals. Data are from four independent experiments. n.s., not significant; *p < 0.05, ** p< 0.01 vs. wild type and respective #, ##, and ### vs. week 1 as indicated.