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. 2018 Sep 25;9:2173. doi: 10.3389/fimmu.2018.02173

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Copyright © 2018 Marschner, Mulay, Steiger, Anguiano, Zhao, Boor, Rahimi, Inforzato, Garlanda, Mantovani and Anders.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTX3 abolishes crystal adhesion molecule expression in vitro and in vivo. (A,B) Primary murine proximal tubular cells were isolated from Ptx3^+/+ and Ptx3^−/− littermate mice with 3 weeks of age and stimulated with PBS and 500 μg/ml CaOx crystals, respectively (n = 4). Total RNA was isolated and transcribed to cDNA. Subsequent qPCR for (A) Cd44 and (B) AnxaII expression was conducted. (C–F) Ptx3^+/+ and Ptx3^−/− female littermates (10–12 weeks of age) were fed with oxalate chow for 3 weeks and formalin kidney sections were stained for (C,D) CD44 and (E,F) Annexin II, respectively (n = 5). n.s., not significant; *p < 0.05, **p < 0.01, ***p < 0.001 vs. wild type and respective ## and ### vs. PBS as indicated.