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. 2018 Sep 25;9:2173. doi: 10.3389/fimmu.2018.02173

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Copyright © 2018 Marschner, Mulay, Steiger, Anguiano, Zhao, Boor, Rahimi, Inforzato, Garlanda, Mantovani and Anders.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of nephrocalcinosis and CKD under hyperoxaluric conditions is strain and sex dependent. Male and female BALB/c, C57BL/6N, and CD-1 mice (8 weeks of age) were fed with control or oxalate chow for 3 weeks (n = 5). (A) Quantification of calcium oxalate crystal deposition was conducted using Pizzolato's method on formalin fixed kidney sections as shown in (B). (C) Quantification of tubular injury was conducted using PAS-stained formalin fixed kidney sections as shown in (D). (E) Quantification of Collagen I deposition was conducted using Collagen I-stained formalin fixed kidney sections as shown in (F). (G) Plasma creatinine, (H) blood urea nitrogen, and (I) plasma phosphorus were analyzed Cobas Integra 800 autoanalyzer. n.s., not significant; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 between treatment groups.