Table 1.
Levels of cytokines in plasma of BD patients and HC.
| Concentration (pg/mL) | Positive subjects (fraction) | |||||
|---|---|---|---|---|---|---|
| BD n = 38 | HC n = 20 | Mann-Whitney U test P value | BD n = 38 | HC n = 20 | Fisher's test P value | |
| IL-1β | 0.01 (0.01–4.73) | 0.01 (0.01–0.01) | 0.0701 | 16/38 | 4/20 | 0.1460 |
| IL-1ra | 53.83 (23.53–188.40) | 32.29 (16.86–80.24) | 0.0830 | 32/38 | 17/20 | 1 |
| IL-2 | 0.01 (0.01–0.01) | n.d. | 0.2875 | 4/38 | 0/20 | 0.2875 |
| IL-4 | 1.78 (0.01–3.55) | 0.01 (0.01–0.01) | 0.0385* | 24/38 | 8/20 | 0.1055 |
| IL-5 | 13.13 (4.55–29.49) | 5.16 (0.01–17.04) | 0.0193* | 30/38 | 11/20 | 0.0734 |
| IL-6 | 0.01 (0.01–13.43) | 0.01 (0.01–0.01) | 0.0180* | 15/38 | 2/20 | 0.0318* |
| IL-7 | 3.20 (0.01–12.51) | 0.01 (0.01–3.56) | 0.0505 | 20/38 | 6/20 | 0.1643 |
| IL-8 | 5.94 (0.01–15.68) | 0.01 (0.01–7.19) | 0.1895 | 25/38 | 11/20 | 0.5700 |
| IL-9 | 13.66 (3.11–47.59) | 8.75 (4.84–16.42) | 0.3514 | 32/38 | 18/20 | 0.7015 |
| IL-10 | 3.58 (0.01–26.73) | 0.01 (0.01–0.01) | 0.0107* | 19/38 | 4/20 | 0.0467* |
| IL-12 (p70) | 7.50 (0.01–27.64) | 0.01 (0.01–13.63) | 0.0624 | 20/38 | 6/20 | 0.1643 |
| IL-13 | 8.13 (4.16–12.54) | 2.79 (0.38–6.24) | 0.0007*** | 38/38 | 15/20 | 0.0034** |
| IL-15 | 0.01 (0.01–0.01) | n.d. | 0.3103 | 3/38 | 0/20 | 0.5443 |
| IL-17A | 8.74 (0.01–48.59) | 0.01 (0.01–10.60) | 0.0420* | 23/38 | 7/20 | 0.0973 |
| Eotaxin | 67.73 (49.59–105.80) | 65.53 (51.11–81.06) | 0.4979 | 38/38 | 20/20 | 1 |
| Basic FGF | 32.02 (8.50–70.16) | 28.40 (12.27–43.76) | 0.5661 | 31/38 | 17/20 | 1 |
| G-CSF | 19.24 (9.22–61.32) | 21.42 (9.51–27.81) | 0.6876 | 32/38 | 18/20 | 0.7015 |
| GM-CSF | 31.63 (8.12–59.66) | 70.10 (0.01–123.80) | 0.2402 | 31/38 | 14/20 | 0.3387 |
| IFN-γ | 44.57 (0.01–171.6) | 21.73 (0.01–54.92) | 0.1801 | 26/38 | 13/20 | 0.7784 |
| IP-10 | 573.40 (356.80–799.60) | 319.00 (310.70–484.10) | 0.0134* | 38/38 | 20/20 | 1 |
| MCP-1 | 0.01 (0.01–37.76) | 0.01 (0.01–0.01) | 0.0267* | 18/38 | 4/20 | 0.0506 |
| MIP-1α | 3.62 (2.20–6.17) | 2.70 (1.87–4.14) | 0.1475 | 37/38 | 19/20 | 1 |
| MIP-1β | 40.62 (23.35–88.57) | 27.25 (20.01–34.36) | 0.0213* | 38/38 | 20/20 | 1 |
| PDGF-BB | 104.90 (28.62–289.3) | 75.69 (27.00–135.80) | 0.4096 | 37/38 | 20/20 | 1 |
| RANTES | 1972 (1156–4954) | 1467 (980.30–3138) | 0.1930 | 38/38 | 20/20 | 1 |
| TNF-α | 21.57 (0.01–92.34) | 12.88 (0.01–21.68) | 0.0620 | 25/38 | 11/20 | 0.5700 |
| VEGF | 12.58 (0.01–32.93) | 6.34 (0.01–17.41) | 0.0810 | 28/38 | 11/20 | 0.2386 |
Cytokine concentrations are expressed in pg/ml as median (IQR). Data were analyzed by Mann-Whitney U test. Fractions represent the number of subjects in which the cytokines were detectable. A cytokine was considered not detectable if its signal was lower than that of the least concentrated cytokine standard. Data were analyzed by Fisher's exact test. n.d., not detected;
*
P < 0.05;
**
P < 0.01;
***
P < 0.001.