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. 2018 Oct;59(10):1531–1537. doi: 10.2967/jnumed.117.206714

FIGURE 3.

FIGURE 3.

Tumor trafficking of 89Zr-oxine–labeled IL13Rα2-CAR T cells in brain. (A) Representative PET/CT scans of NSG mice with or without PBT030-2 ffLuc-positive tumors in left cortex at 140 h after treatment with 89Zr-oxine–labeled IL13Rα2-CAR T cells (70 kBq/106 cells). In mice receiving intraventricular injections (I.C.V.), labeled CAR T cells were injected into cerebrospinal fluid via right ventricle. Intratumoral injections were administered intracranially (I.C.T.) into left cortex. Arrows represent tumor location. (B) Immunohistochemistry for human CD3 (brown) showing trafficking of I.C.V.-delivered IL13Rα2-CAR T cells to contralateral PBT030-2 ffLuc-positive tumors. Scale bar is 250 μm.