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Guanylate cyclase domains and the effect on GUCY2D mutations on the enzyme function. Dependent on the localization, mutations can have several consequences on GC-E function. Localization of the investigated mutations is given. ECD, extracellular domain; TMD, transmembrane domain; JMD, juxtamembrane domain; KHD, kinase homology domain; DD, dimerization domain; CCD, cyclase catalytic domain.
