Table 5.

Summary of all variant screening studies of TREM2 in patients with Alzheimer's disease (AD)

Ethnicity	AD patients	TREM2 variants in AD patients
		exon 2	exon 3	exon 4
Caucasian	256 European + 836 North American [5]	Q33X, Y38C, R47H, R62H, T66M, D87N, T96K, R98W	R136Q, H157Y	-
	117 Norwegian + 944 Dutch +	R47H	-	-
	517 German + 3,759 Icelandic +
	399 US [4]
	726 French [13]	Q33X, R47H, R62H, R62C, D87N, T96K	-	-
	427 American [14]	R47H	-	-
	504 Spanish [15]	R47H, R62H	-	-
	3,172 Spanish [16]	R47H	-	-
	1,216 Belgian [11]	D39G, D39E, R47H, G58A, R62H, D87N, T96K	L133L, H157Y	S162R, L211P, T223I
	2,082 US [10]	Q33X, R47H, R52H, R62H, T66M, D87N, T96K	R136W, R136Q, H157Y	W191X, E202D, L211P, H215Q, T223I
	210 North American [17]	R47H, D87N,	H157Y	L205P, G219C
East Asian	1,133 Chinese [18]	V34V, C110C, H114H, G115S	-	-
	360 Chinese [19]	A130V	-	-
	988 Chinese [20]	-	H157Y	S183C, A192T
	400 Korean [21]	-	H157Y	A192T
	2,190 Japanese [22]	R47H,	H157Y	L211P
African American	899 African American [23]	R47H, R62H, D87N	E151K,	W191X, L211P
Others	131 Iranian [24]	R47H, G55R, R62H, R62C	-	-

Variations significantly associated with AD are underlined.