Table 1.
Effect of ML246 and cisplatin on SKOV3 xenograft growth and spread
| Mouse ID | Treatment | Primary tumor volume(mm3) | Lesions outside of primary site (#) | Total # extraovarian lesions |
|---|---|---|---|---|
| 201 | cisplatin | 195.7 | 0 | |
| 203 | cisplatin | 738.2 | 0 | |
| 204 | cisplatin | 70.3 | 0 | |
| 205 | cisplatin | 287.3 | 0 | |
| 207 | cisplatin | 208.9 | back/subQ (1) | 1 |
| 211 | cisplatin | 25.9 | back/subQ (1) | 1 |
| 214 | cisplatin | 51.2 | 0 | |
| 217 | cisplatin | NR | mouse died | |
| 229 | cisplatin | NT | 0 | |
| 234 | cisplatin | 93.3 | back/subQ (1) | 1 |
| 206 | vehicle | small | back/subQ (1) | 1 |
| 208 | vehicle | NR | mouse died | |
| 209 | vehicle | 172.6 | back/subQ (1) | 1 |
| 210 | vehicle | 118.3 | 0 | |
| 212 | vehicle | 11.7 | pelvis (1); back/subQ (1) | 2 |
| 221 | vehicle | 3.4 | 0 | |
| 222 | vehicle | 35.9 | cecum (1); | 1 |
| 224 | vehicle | 323.8 | diaphram (2); pelvis (1); bowel (1); back/subQ (1); mesentery (1) | 6 |
| 225 | vehicle | 184.4 | back/subQ (1) | 1 |
| 223 | vehicle | 212.0 | 0 | |
| 230 | vehicle | 234.0 | bowel (2) | 2 |
| 233 | vehicle | small | pelvis (1) | 1 |
| 202 | ML246 | NR | mouse died | |
| 213 | ML246 | 14.3 | 0 | |
| 215 | ML246 | NT | 0 | |
| 216 | ML246 | 140.7 | back/subQ (1) | 1 |
| 218 | ML246 | NR | mouse died | |
| 219 | ML246 | 114.6 | back/subQ (1) | 1 |
| 220 | ML246 | 917.4 | 0 | |
| 226 | ML246 | NT | back/subQ (2) | 2 |
| 227 | ML246 | NR | mouse died | |
| 228 | ML246 | NT | 0 | |
| 231 | ML246 | NT | 0 | |
| 232 | ML246 | 213.3 | 0 |
NT No tumor, SubQ Subcutaneous, NR Not recorded