Table 1.
Examples of known GPCR-endogenous ligand pairs with matching disease indications and corresponding Open Targets overall scores
| Disease | GPCR Name |
Score | Endogenous ligand Name |
Score |
|---|---|---|---|---|
| Epilepsy | GALR2 | 0.02 | GAL | 1.00 |
| Obesity | MC1R | 0.04 | POMC | 1.00 |
| Alzheimer’s disease | FPR2 | 0.04 | APP | 1.00 |
| Inflammatory bowel disease | CCR3 | 0.05 | CCL7 | 0.87 |
| Hypertension | AGTR2 | 0.15 | AGT | 1.00 |
| Rheumatoid arthritis | CCR6 | 0.99 | CCL20 | 0.06 |
| Macular degeneration | CX3CR1 | 1.00 | CX3CL1 | 0.05 |
| Biliary dyskinesia | SCTR | 1.00 | VIP | 0.02 |
| osteoporosis | CALCR | 1.00 | ADM | 0.04 |
| vascular disease | EDNRA | 1.00 | EDN2 | 0.04 |