Table 2.
Anthropometric Measures (Body Mass Index; Weight; Height; Waist Circumference; Overall and Abdominal Obesity; Percentage Body Fat), Fasting Insulin and Glucose, Post-Oral Glucose Tolerance Test Response, and Diabetic Control Characteristics Weighted Means (Standard Deviations) or Frequencies across rs7903146 Genotypes (n = 9031) at the Hispanic Community Health Study/Study of Latinos Baseline Examination
| CC | CT | TT | P-value | |
|---|---|---|---|---|
| Unweighted total analytic sample size | n = 5040 | n = 3373 | n = 618 | |
| Measured BMIa (kg/m2) | 29.74 (0.17) | 29.26 (0.13) | 29.21 (0.28) | 0.06 |
| Self-Reported BMIa (kg/m2) | 29.81 (0.17) | 29.34 (0.13) | 29.23 (0.27) | 0.05 |
| Measured Weight (kg) | 80.09 (0.52) | 78.71 (0.39) | 78.58 (0.79) | 0.1 |
| Self-Reported Weight (kg) | 80.29 (0.53) | 78.94 (0.39) | 78.69 (0.76) | 0.1 |
| Measured Height (cm) | 163.93 (0.18) | 163.83 (0.19) | 163.94 (0.32) | 0.9 |
| % Overall Measured Obesity (≥30 kg/m2 Measured BMI) | 42.43% | 37.89% | 38.55% | 0.03 |
| % Overall Self-Reported Obesity (≥30 kg/m2 Self-Reported BMI) | 43.29% | 38.85% | 37.66% | 0.03 |
| Waist Circumference (cm) | 98.41 (0.40) | 97.37 (0.31) | 97.34 (0.65) | 0.09 |
| % Abdominal Measured Obesity (≥120 cm for men; ≥88 cm for women) | 56.1% | 55.2% | 57.1% | 0.7 |
| % Body Fat | 33.58 (0.21) | 32.96 (0.19) | 33.18 (0.4) | 0.08 |
| % Identified as Diabetic Before or at Baseline Examinationb | 14.77% | 18.24% | 21.01% | 0.0002 |
| Unweighted non-diabetic subsample | n = 4107 | n = 2586 | n = 454 | |
| Fasting Insulin (mU/L) | 11.98 (0.2) | 11.96 (0.19) | 11.53 (0.47) | 0.7 |
| Fasting Glucose (mg/dL) | 93.78 (0.18) | 94.12 (0.23) | 94.67 (0.51) | 0.2 |
| HOMA Index of Beta Cell Function | 145.17 (2.59) | 140.81 (2.33) | 133.28 (4.81) | 0.07 |
| HOMA Index of Insulin Resistance | 2.82 (0.05) | 2.84 (0.05) | 2.75 (0.12) | 0.8 |
| post OGTT Insulin (mU/L)c | 78.06 (1.81) | 81.09 (1.84) | 75.39 (3.2) | 0.2 |
| post OGTT, Glucose (mg/dL)c | 112.25 (0.78) | 114.23 (0.85) | 115.85 (1.6) | 0.06 |
| Glycated Hemoglobin (mmol/mol) | 35.77 (0.1) | 35.99 (0.1) | 35.72 (0.22) | 0.2 |
| % Glycated Hemoglobin | 5.42 (0.01) | 5.44 (0.01) | 5.41 (0.02) | 0.2 |
| Unweighted diabetic b subsample | n = 933 | n = 787 | n = 164 | |
| Glycated Hemoglobin (mmol/mol) | 57.55 (1.25) | 57.79 (0.94) | 60.06 (2.06) | 0.6 |
| % Glycated Hemoglobin | 7.42 (0.11) | 7.44 (0.09) | 7.64 (0.19) | 0.6 |
| % Controlled Diabetes (< 7% Glycated Hemoglobin) | 26.1% | 31.2% | 35.3% | 0.1 |
All weighted means and standard deviations (or percentages) for anthropometric measures (weight, height, body mass index, waist circumference, fat percentage, overall and abdominal obesity) were estimated from regression models, which accounted for the complex sampling design and age, sex, and ancestry proportions. Additionally, all other weighted means and standard deviations (or percentages) were adjusted for body mass index (BMI) at examination. rs7903146 genotypes were modeled dis-jointly (i.e. no additive model was assumed)
aMeasured and self-reported BMI values at baseline were based off of measured weight and height, and self-reported weight and measured height, respectively
bThe diabetes subsample included individuals reporting having received a previous diabetes diagnosis at baseline examination, or being identified as diabetic at the baseline examination
c2-h Oral Glucose Tolerance Test (OGTT) was conducted in only individuals who did not report having had a previous diabetes diagnosis