Table 7.
Regression analysis for prediction of T2DM within healthy control subjects
| Univariable
|
Multivariable
|
|||||||
|---|---|---|---|---|---|---|---|---|
| P | OR | 95% CI | P | OR | 95% CI | |||
| Age (years) | 0.154 | 1.156 | 0.094 | 1.221 | ||||
| Gender | 0.447 | 2.180 | 0.011 | 4.702 | ||||
| BMI (kg/cm2) | 0.017 | 1.155 | 1.027 | 1.299 | 0.027 | 1.396 | 1.192 | 1.900 |
| Triglycerides (mg/dL) | <0.001 | 1.017 | 1.008 | 1.025 | <0.001 | 1.003 | 1.002 | 1.005 |
| Total cholesterol (mg/dL) | 0.002 | 1.026 | 1.009 | 1.042 | <0.001 | 1.009 | 1.007 | 1.011 |
| HDL-C (mg/dL) | <0.001 | 0.978 | 0.967 | 0.989 | <0.001 | 0.990 | 0.988 | 0.993 |
| LDL-C (mg/dL) | <0.001 | 1.016 | 1.007 | 1.024 | 0.376 | 1.299 | 1.098 | 1.901 |
| Fasting blood glucose (mg/dL) | <0.001 | 1.002 | 1.001 | 1.004 | <0.001 | 1.003 | 1.002 | 1.005 |
| FPI | 0.002 | 1.552 | 1.170 | 2.058 | 0.004 | 1.075 | 1.023 | 1.130 |
| HOMA-IR | <0.001 | 1.123 | 1.060 | 1.189 | 0.003 | 1.868 | 1.792 | 1.952 |
| HBA1C (%) | <0.001 | 1.332 | 1.158 | 1.533 | <0.001 | 1.150 | 1.120 | 1.181 |
| rs1801278 (GA+AA) | 0.011 | 3.857 | 1.366 | 10.890 | <0.001 | 1.076 | 1.039 | 1.115 |
Abbreviations: BMI, body mass index; FPI, fasting plasma insulin; HDL-C, high-density lipoprotein cholesterol; HOMA, homeostatic model assessment; IR, insulin resistance; LDL-C, low-density lipoprotein cholesterol; T2DM, type 2 diabetes mellitus.