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. 2018 Sep 28;11:6305–6316. doi: 10.2147/OTT.S172152

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© 2018 Han et al. This work is published and licensed by Dove Medical Press Limited

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miR-218 exerts anticancer effects in PTC via inactivation of PTEN/PI3K/AKT pathway by targeting Runx2 in vitro.

Notes: After TPC-1 cells were transfected with miR-218 alone or in combination with pcDNA-Runx2, cell viability, invasion, and apoptosis were examined by (A) CCK-8 assay, (B) Transwell invasion assay, and (C) flow cytometry analysis, respectively. (D and E) The protein levels of phosphorylated AKT (p-AKT) (Ser473), total AKT (t-AKT), and PTEN were determined by Western blot in TPC-1 cells transfected with si-Runx2, miR-218, miR-218+ pcDNA-Runx2, or respective controls blot. *P<0.05.

Abbreviations: CCK-8, cell counting kit-8; PTC, papillary thyroid cancer.