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. 2018 Sep 28;13:5909–5924. doi: 10.2147/IJN.S175608

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© 2018 Li et al. This work is published and licensed by Dove Medical Press Limited

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Effects of nano-TiO₂ on MMP in primary cultured LCs.

Notes: (A) Flow-cytometry images of mitochondrial injury in LCs treated with different nano-TiO₂ concentrations. (B) MMP levels calculated as JC-1 polymer vs JC-1 monomer in LCs treated with different nano-TiO₂ concentrations (***P<0.001). MMP reduction in LCs was observed in the presence of nano-TiO₂. Values represent means ± SD (n=5).

Abbreviations: JC-1, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide; LCs, Leydig cells; nano-TiO₂, nanoparticulate TiO₂; UL, upper left; UR, upper right; LL, lower left; LR, lower right; PE, P-phycoerythrin; MMP, mitochondrial membrane potential.