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. 2018 Sep 25;9:412. doi: 10.3389/fgene.2018.00412

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Copyright © 2018 Piñero, Gonzalez-Perez, Guney, Aguirre-Plans, Sanz, Oliva and Furlong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic features of the sets of genes, and of the protein classes. We plot the z-score resulting from 10,000 randomizations. The asterisks indicate that the z-score is statically significant (p-value < 0.05). TARGET: drug targets, METAB: proteins that are involved in the drug metabolism, absorption, distribution, metabolism, and excretion. TOXPROT: proteins associated to side effects. TT: genes in common between drug targets and toxicity genes. OT: only TARGET proteins. OTP: only TOXPROT proteins. See Figure 1 for more details. It is worth noting that while 90% genes from the total of 1,934 TARGET genes are classified in the 7 target classes, 40% of the TOXPROT set belongs to other protein classes (Unclassified set).