Table 2.

Enrichment analysis of the cartographic roles of each set of genes in the INBIOMAP global interactome.

Cartographic role	TARGET	TT	OT	METAB	TOXPROT	OTP
Kinless hub	3.4 (1.2e–14)	4.2 (8.7e–15)	1.7 (0.09)	0.66 (1.0)	2.6 (1.1e–11)	1.3 (1.1e–01)
Connector hub	1.4 (2.2e–01)	2.2 (1.9e–02)	0.46 (1.0)	0.32 (1.0)	1.4 (1.0e–01)	1 (7.8e–01)
Provincial hub	3.5 (2.0e–01)	1.6 (7.9e–01)	5.1 (0.19)	0 (1.0)	1.4 (7.8e–01)	1.2 (8.5e–01)
Kinless	1.7 (1.5e–13)	1.9 (1.7e–12)	1.3 (0.02)	1 (0.78)	2 (3.5e–40)	1.8 (3.8e–23)
Connector	1.1 (1.0e–01)	1.1 (1.1e–01)	1.1 (0.54)	0.86 (1.0)	1.2 (1.7e–03)	1.1 (1.6e–02)
Peripheral	0.85 (1.0)	0.74 (1.0)	1 (0.6736)	0.93 (1.0)	0.8 (1.0)	0.86 (1.0)
Ultra-peripheral	0.55 (1.0)	0.49 (1.0)	0.69 (1.0)	1.3 (0.06)	0.55 (1.0)	0.62 (1.0)

The fold enrichment of the Fisher’s exact test is shown with the corresponding p-value corrected by the Benjamini and Hochberg method between parentheses. The cartographic partition of the different gene sets in the INBIOMAP and HIPPIE interactomes is provided in Supplementary Table S3.