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. 2018 Sep 25;9:939. doi: 10.3389/fphar.2018.00939

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Copyright © 2018 Šarenac and Mikov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enterohepatic recirculation of bile salts. Bile salts entering the intestinal tract may be absorbed into the portal circulation where they can be removed from systemic circulation by hepatic uptake. The compound may then be excreted into the bile and pass back into the intestinal tract and become available for enterohepatic cycling. Biotransformation in enterocytes, hepatocytes, and the intestinal tract and throughout the body can convert the drug into metabolites, which may undergo enterohepatic cycling or escape into the urine and feces. Some very lipophilic solutes may bypass the portal circulation and be absorbed into the systemic circulation via the lymphatic system (Mikov et al., 2007).