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. Author manuscript; available in PMC: 2018 Oct 2.
Published in final edited form as: J Am Coll Cardiol. 2018 Aug 21;72(8):835–837. doi: 10.1016/j.jacc.2018.07.006

FIGURE 1.

FIGURE 1

Potential Stress-Induced Fibrotic Stimuli

Prolapse (1) induces papillary muscle (PM) traction (2) and basal LV wall tension (3), augmented by systolic annular expansion, (4) as potential fibrotic stimuli (5). (Courtesy of Mark Handschumacher.) AO = aorta; LA = left atrium; LV = left ventricle; PM = papillary muscle.