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. Author manuscript; available in PMC: 2018 Oct 2.
Published in final edited form as: Heart. 2018 Jan 19;104(12):978–984. doi: 10.1136/heartjnl-2017-312420

Figure 2.

Figure 2

Filamin A: a hub protein involved in mechanotransduction pathways. Dimers of Filamin A protein organise the filamentous actin network and participate, through their interactions with >80 binding partners, to many signalling pathways including: transforming growth factor (TGF)-β and tyrosine kinase receptors, integrin macromolecular complex, mechanosensitive channels (Piezzo) and actin/actomyosin homeostasis. All these signalling pathways are modulated by mechanical stress symbolised by red marks. The location of mitral valve prolapse (MVP)-associated Filamin-A mutations is indicated by yellow stars.