Fig 1.

(A) Common strategies employed in chemotherapy and in adaptive therapy to deal with the proliferation of malignant cells. In adaptive therapy, treatment is used sparingly and in a temporally dynamic fashion, and this both increases the competitive advantage of chemo-sensitive cells and maintains a stable tumor burden. B) In a similar manner, when the immune system kills only some sensitive/visible tumor cells, it allows for maintenance of a stable tumor burden because this population competes with cells that are resistant to immune attack.