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. 2018 Oct 1;150(10):1360–1372. doi: 10.1085/jgp.201711979

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© 2018 Burger et al.

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Figure 8. — Probe dependence as a consequence of biased modulation at the M₂ mAChR. Cooperativity values of LY2033298 for different orthosteric agonists at the M₂ mAChR from ERK1/2 phosphorylation assays. Note that the magnitude and direction of the allosteric effect are not related to the degree of intrinsic efficacy of the orthosteric agonist. Data represent mean ± SEM and are replotted from Valant et al. (2012).