Table 1. Structures of mAChRs.

Receptor	Ligand	Ligand type	Protein Data Bank accession number	Resolution (Å)	Reference
M1R-T4L	Tiotropium	Inverse agonist	5CXV	2.7	Thal et al., 2016
M2R-T4L	QNB	Inverse agonist	3UON	3.0	Haga et al., 2012
M2R•Nb9.8	Iperoxo	Agonist	4MQS	3.5	Kruse et al., 2013
M2R•Nb9.8	Iperoxo + LY2119620	Agonist + PAM	4MQT	3.7	Kruse et al., 2013
M3R-T4L	Tiotropium	Inverse agonist	4DAJ	3.4	Kruse et al., 2012
M3R-dsT4L	Tiotropium	Inverse agonist	4U14	3.6	Thorsen et al., 2014
M3R-mT4L	Tiotropium	Inverse agonist	4U15	2.8	Thorsen et al., 2014
M3R-mT4L	NMS	Inverse agonist	4U16	3.7	Thorsen et al., 2014
M4R-mT4L	Tiotropium	Inverse agonist	5DSG	2.6	Thal et al., 2016