Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 1;217(10):3747–3765. doi: 10.1083/jcb.201802057

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Risher et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — Lack of α2δ-1 results in decreased excitatory synaptic function. (A) Recordings were made from LII/III pyramidal neurons in V1 at P21. (B) mEPSC traces from WT and α2δ-1 KO pyramidal neurons. (C and D) Frequency (C, left), interevent interval (C, right), and amplitude (D) of mEPSCs from WT and α2δ-1 KO neurons (n = total of 12 cells from three animals/genotype). Left: Two-tailed t test. Right: Kolmogorov–Smirnov test. (E) mIPSC traces from WT and α2δ-1 KO pyramidal neurons. (F and G) Frequency (F, left), interevent interval (F, right), and amplitude (G) of mIPSCs from WT and α2δ-1 KO neurons (n = total of 10 cells from three animals/genotype). Left: Two-tailed t test. Right: Kolmogorov–Smirnov test. (H) Traces of NMDA-only and AMPA-only evoked currents from WT and α2δ-1 KO pyramidal neurons. (I) Quantification of NMDA/AMPA ratio between WT and α2δ-1 KO (n = total of 12 cells from three to four animals/genotype). Two-tailed t test. Error bars represent SEM. (J) Traces from paired pulse recordings from WT and α2δ-1 KO neurons. (K) Comparison of PPR between WT and α2δ-1 KO (n = total of 12 cells from three to four animals/genotype). One-way ANCOVA. Error bars represent SEM. *, P < 0.05; ***, P < 0.0001.