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. 2018 Oct 1;217(10):3640–3655. doi: 10.1083/jcb.201711002

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© 2018 Mejlvang et al.

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Figure 2. — The rapid degradation triggered by amino acid starvation is dependent on the lysosome. (A) SILAC experiment where bafilomycin A1 (Baf; 200 nM) was used to block lysosomal-mediated protein degradation in BJ cells during 4-h starvation in HBSS. (B) Dot plot of expression changes induced by lysosomal inhibition (Baf) during 4 h in HBSS. (C) Dot plot of expression changes of all proteins identified in both the BJ-starveome and the bafilomycin dataset. (D) Overlap of identified proteins from the two biological replicas (left), and the overlap between the BJ-starveome and bafilomycin dataset (right). (E) Dot plot representation of the 100 most degraded proteins in both the HBSS:Full media and the HBSS+Baf:HBSS experiments in BJ cells. The lower part shows the 20 most degraded proteins.