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. 2018 Aug 14;59(10):1906–1915. doi: 10.1194/jlr.M085886

Fig. 6.

Fig. 6.

Silence of AT1R cancels the effect of Ang II on ABCA1 expression and cholesterol accumulation. A: The expression of AT1R in AT1R silenced INS-1 cells. B, C: Silence of AT1R canceled the effect of Ang II on ABCA1 expression by Western blotting (B) and real-time PCR (C). D, E: Cholesterol content and Oil Red O stain in INS-1 cells after silence of AT1R. D: Percentage of cholesterol content per cell is referred to control. A graph showing the mean ± SEM (n = 3) of separate experiments for each treatment group is provided. E: Oil Red O stain. The left line was siControl group, and the right line was siAT1 receptor group. The images were 400× magnification (bar = 10 µm). 0, no treatment; Ang II, treatment with Ang II at a concentration of 10 nM for 24 h. * P < 0.05 compared with control; # P < 0.05 compared with Ang II. N.S., no significance.