TABLE 2.
Lead-hit compounds in FDA chemical library altering levels of Des
| WT-N2a Cells Only | Common | D7-N2a Cells Only | ||||
| Drug | Z score | Drug | Z Score | Drug | Z score | |
| WT-N2a | D7-N2a | |||||
| Amfenac | 11.7 | Imatinib | 9.4 | 8.5 | Bazedoxifene | 7.9 |
| Sulfamethizole | 9.5 | Pregnenolone | 10.3 | 9.9 | Clomiphene | 4.8 |
| Gefitinib | 8.8 | Masitinib | 8.0 | 5.5 | Orphenadrine | 4.2 |
| Bosutinib | 8.3 | Progesterone | 8.8 | 7.8 | Tolmetin | 3.3 |
| Natamycin | 4.7 | Vandetanib | 5.5 | 3.7 | Idoxuridine | 3.3 |
| Carmofur | 4.3 | Ponatinib | 4.7 | 4.4 | Rosuvastatin | −3.0 |
| Asenapine | 4.1 | Clemastine | 3.7 | 5.4 | Cabozantinib | −3.1 |
| Zaltoprofen | 4.1 | Raloxifene | 3.5 | 8.0 | ||
| Dutasteride | 4.0 | Darifenacin | 3.0 | 3.0 | ||
| Teniposide | 3.9 | Toremifene | 3.0 | 6.2 | ||
| Mepivacaine | 3.9 | Simvastatin | −3.2 | −4.0 | ||
| Fulvestrant | 3.7 | Mevastatin | −3.9 | −3.6 | ||
| Etoposide | 3.6 | Sulconazole | −4.0 | −3.1 | ||
| Methylprednisolone | 3.6 | Amorolfine | −4.5 | −3.9 | ||
| Estradiol cypionate | 3.4 | Fluvastatin | −4.6 | −4.2 | ||
| Mercaptopurine | 3.4 | Fenticonazole | −4.6 | −4.0 | ||
| Topotecan | 3.3 | Butoconazole | −4.7 | −4.1 | ||
| Amlodipine | 3.1 | Pitavastatin | −4.7 | −4.2 | ||
| Domiphen | −3.0 | |||||
| Cetrimonium | −3.2 | |||||
| Trimebutine | −3.5 | |||||
| Bifonazole | −3.6 | |||||
| Econazole | −3.9 | |||||
| Clotrimazole | −4.0 | |||||