TABLE 1.
Demographic characteristics of the study participants
| Discovery Cohort (mean ± SD) | Replication Cohort (mean ± SD) | P for Differences between Discovery and Replication Cohorts | |
| Sex (male:female) | 667:686 | 673:503 | 7.96E-05 |
| Age (years ± SD) | 46.77 ± 13.79 | 46.79 ± 10.65 | 0.967 |
| Weight (kg ± SD) | 88.51 ± 21.12 | 92.38 ± 16.97 | 3.62E-06 |
| Height (cm ± SD) | 165.29 ± 9.60 | 166.45 ± 8.91 | 0.0057 |
| BMI (kg/m2 ± SD) | 32.42 ± 7.38 | 31.24 ± 5.70 | 6.15E-06 |
| WC (cm ± SD) | 102.21 ± 16.35 | 100.53 ± 12.05 | 0.003 |
| LDL (mmol/l ± SD) | 3.07 ± 0.97 | 3.40 ± 0.92 | <2.2E-16 |
| HDL (mmol/l ± SD) | 1.13 ± 0.38 | 1.13 ± 0.32 | 0.8213 |
| TC (mmol/l ± SD) | 4.92 ± 1.11 | 5.22 ± 1.04 | 7.77E-12 |
| TG (mmol/l ± SD) | 1.69 ± 1.18 | 1.56 ± 1.00 | 0.0016 |
| HbA1c (mmol/l ± SD) | 7.10 ± 2.08 | 6.00 ± 1.44 | <2.2E-16 |
| FPG (mmol/l ± SD) | 7.31 ± 3.57 | 5.86 ± 2.27 | <2.2E-16 |
| SBP (mmHg ± SD) | 127.61 ± 17.51 | 129.07 ± 16.72 | 0.062 |
| DBP (mmHg ± SD) | 77.86 ± 10.60 | 78.72 ± 11.10 | 0.035 |
| Obesity (BMI ≥30 kg/m2) (yes:no)a | 803: 550 | 535: 641 | 7.43E-05 |
| Diabetic (yes:no) | 605:748 | 452:724 | 0.0016 |
| Hypertensive (yes:no) | 607:746 | 420:756 | 3.61E-06 |
| Lipid lowering medication (yes:no) | 133:1,220 | 4:1,162 | <2.2E-16 |
| Anti-diabetes medication (yes:no) | 216:1,137 | 54:1,122 | <2.2E-16 |
| Anti-hypertensive medication (yes:No) | 161:1,192 | 85:1,091 | 0.00010 |
HbA1c, glycated hemoglobin; SBP, systolic blood pressure; DBP, diastolic blood pressure.
a
The distribution of the participants onto normal weight (BMI 20 to <25 kg/m2), overweight (BMI 25 to <30 kg/m2), obese (BMI 30 to <40 kg/m2), morbid obese (BMI ≥40 kg/m2) = 222:328:597:206 in the discovery cohort and 93:442:559:82 in the replication cohort.