TABLE 2.
Results of the statistical association tests from the discovery, replication, and meta-analysis phases with TG (P approaching genome-wide significance at ≤6.12E-09) when modeled for the recessive mode of inheritance
| SNP: Effect Allele | Gene: Functional Consequences | Phase | Effect Sizea | a | Effect Sizeb | b | Effect Sizec | c | Effect Sized | d |
| rs1002487: C | RPS6KA1: intron | Discovery | 3.337 | 7.17E-11 | 3.344 | 6.69E-11 | 3.402 | 1.91E-11 | 3.202 | 3.32E-10 |
| Replication | 1.036 | 0.01805 | 1.045 | 0.0165 | 1.062 | 0.01508 | 1.029 | 0.01765 | ||
| Meta | 6.517 | 7.17E-11 | 6.197 | 5.76E-10 | 6.532 | 6.49E-11 | 6.18 | 6.42E-10 | ||
| rs11805972: T | LAD1: P > Q | Discovery | 2.481 | 8.55E-11 | 2.48 | 8.79E-11 | 2.467 | 7.12E-11 | 2.404 | 2.54E-10 |
| Replication | 1.893 | 4.03E-08 | 1.878 | 4.50E-08 | 1.861 | 6.26E-08 | 1.835 | 7.98E-08 | ||
| Meta | 8.485 | 2.16E-17 | 8.351 | 6.75E-17 | 8.451 | 2.89E-17 | 8.281 | 1.23E-16 | ||
| rs7761746: A | OR5V1: synonymous | Discovery | 2.447 | 1.89E-09 | 2.443 | 2.08E-09 | 2.37 | 4.31E-09 | 2.49 | 7.36E-10 |
| Replication | 0.8277 | 9.97E-03 | 0.8443 | 7.88E-03 | 0.7594 | 1.62E-02 | 0.8576 | 6.44E-03 | ||
| Meta | 6.066 | 1.31E-09 | 6.229 | 4.68E-10 | 5.85 | 4.91E-09 | 6.277 | 3.45E-10 | ||
| rs39745: T | CTTNBP2, LSM8: intergenic | Discovery | 1.485 | 3.63E-09 | 1.486 | 3.56E-09 | 1.427 | 1.09E-08 | 1.473 | 3.76E-09 |
| Replication | 0.4809 | 3.69E-02 | 0.4769 | 3.95E-02 | 0.5116 | 0.02603 | 0.5255 | 0.0221 | ||
| Meta | 5.643 | 1.67E-08 | 5.619 | 1.92E-08 | 5.613 | 1.99E-08 | 5.782 | 7.39E-09 | ||
| rs2934952: G | PGAP3: intron | Discovery | 0.773 | 3.17E-09 | 0.7722 | 3.38E-09 | 0.7527 | 5.95E-09 | 0.7617 | 4.21E-09 |
| Replication | 0.3243 | 6.87E-03 | 0.3167 | 7.94E-03 | 0.2927 | 1.35E-02 | 0.3152 | 7.66E-03 | ||
| Meta | 6.086 | 1.16E-09 | 6.054 | 1.41E-09 | 5.859 | 4.67E-09 | 6.03 | 1.64E-09 | ||
| rs9626773: A | RP11-191L9.4, CERK: intergenic | Discovery | 2.848 | 1.42E-09 | 2.857 | 1.29E-09 | 2.751 | 3.65E-09 | 2.93 | 3.56E-10 |
| Replication | 3.395 | 8.60E-07 | 3.315 | 1.54E-06 | 3.368 | 9.85E-07 | 3.313 | 1.26E-06 | ||
| Meta | 7.776 | 7.47E-15 | 7.855 | 4.00E-15 | 7.647 | 2.06E-14 | 7.882 | 3.21E-15 |
Effect size represents β value for the discovery and replication phases and Z-score for meta-analysis.
a
Regular correction: corrected for age, sex, and the top 10 principal components that resulted from the PCA of the genotype data.
b
Corrected for lipid medication in addition to the regular correction.
c
Corrected for obesity (using BMI as the characterizing trait) in addition to the regular correction.
d
Corrected for diabetes status in addition to the regular correction.