Table 3.
T-cell density stratified by race and molecular classification in matched race tissue microarrays and combined African-American set
| CD3 Density
|
CD8 Density
|
FOXP3 Density
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Matched race tissue microarrays |
N | Median | p* | N | Median | p* | N | Median | p* |
| Overall | 224 | 232.1 | 227 | 55.7 | 227 | 15.9 | |||
| PTEN Intact | 168 | 192.3 | 0.001 | 171 | 49.5 | 0.04 | 171 | 11.5 | 0.0004 |
| PTEN Loss | 56 | 317.4 | 56 | 68.5 | 56 | 26.1 | |||
| ERG Negative | 137 | 188.3 | 0.0004 | 140 | 43.3 | 0.001 | 140 | 11.9 | 0.001 |
| ERG Positive | 87 | 308.6 | 87 | 69.9 | 87 | 20.3 | |||
| PTEN Intact & ERG Negative | 118 | 184.8 | 0.0001 | 121 | 42.4 | 0.01 | 121 | 10.6 | <0.0001 |
| PTEN Intact & ERG Positive | 50 | 229.5 | 50 | 74.7 | 50 | 12.8 | |||
| PTEN Loss & ERG Negative | 19 | 244.0 | 19 | 59.2 | 19 | 20.3 | |||
| PTEN Loss & ERG Positive | 37 | 365.2 | 37 | 69.0 | 37 | 30.9 | |||
| European-American | |||||||||
| PTEN Intact | 91 | 192.8 | 0.005 | 91 | 50.4 | 0.2 | 91 | 12.4 | 0.01 |
| PTEN Loss | 36 | 305.8 | 36 | 69.4 | 36 | 25.2 | |||
| ERG Negative | 64 | 190.1 | 0.005 | 64 | 42.4 | 0.01 | 64 | 10.2 | 0.01 |
| ERG Positive | 63 | 299.5 | 63 | 69.9 | 63 | 19.5 | |||
| PTEN Intact & ERG Negative | 54 | 181.7 | 0.004 | 54 | 42.0 | 0.1 | 54 | 9.3 | 0.004 |
| PTEN Intact & ERG Positive | 37 | 224.6 | 37 | 77.8 | 37 | 13.3 | |||
| PTEN Loss & ERG Negative | 10 | 237.0 | 10 | 68.1 | 10 | 20.3 | |||
| PTEN Loss & ERG Positive | 26 | 379.8 | 26 | 69.4 | 26 | 31.8 | |||
| African-American | |||||||||
| PTEN Intact | 77 | 191.9 | 0.1 | 80 | 46.0 | 0.1 | 80 | 11.5 | 0.03 |
| PTEN Loss | 20 | 337.8 | 20 | 59.2 | 20 | 29.2 | |||
| ERG Negative | 73 | 188.3 | 0.04 | 76 | 44.2 | 0.1 | 76 | 12.8 | 0.03 |
| ERG Positive | 24 | 311.2 | 24 | 70.3 | 24 | 28.7 | |||
| PTEN Intact & ERG Negative | 64 | 187.0 | 0.1 | 67 | 43.3 | 0.3 | 67 | 11.5 | 0.02 |
| PTEN Intact & ERG Positive | 13 | 234.3 | 13 | 71.6 | 13 | 9.7 | |||
| PTEN Loss & ERG Negative | 9 | 306.8 | 9 | 53.9 | 9 | 16.5 | |||
| PTEN Loss & ERG Positive | 11 | 352.8 | 11 | 69.0 | 11 | 30.9 | |||
|
| |||||||||
| Combined African American** | |||||||||
| PTEN Intact | 149 | 234.3 | 0.03 | 150 | 54.8 | 0.1 | 153 | 14.2 | 0.05 |
| PTEN Loss | 32 | 355.9 | 32 | 71.6 | 32 | 28.3 | |||
| ERG Negative | 144 | 235.6 | 0.01 | 147 | 53.9 | 0.1 | 148 | 15.0 | 0.04 |
| ERG Positive | 37 | 313.9 | 35 | 78.7 | 37 | 28.3 | |||
| PTEN Intact & ERG Negative | 127 | 230.0 | 0.03 | 130 | 50.9 | 0.2 | 131 | 14.2 | 0.1 |
| PTEN Intact & ERG Positive | 22 | 287.1 | 20 | 87.1 | 22 | 14.2 | |||
| PTEN Loss & ERG Negative | 17 | 306.8 | 17 | 93.8 | 17 | 16.8 | |||
| PTEN Loss & ERG Positive | 15 | 359.0 | 15 | 69.0 | 15 | 30.1 | |||
*
Kruskal-Wallis test
**
African-Americans from matched race tissue microarrays (above) and high grade African-American tissue microarray (see Supplementary Table S4)